The historic Vernon Manor is reopening on Thursday as administrative offices for Cincinnati Children's Hospital Medical Center.
The original Vernon Manor hotel opened in 1924, but closed its doors in 2009 for economic reasons.
The facility will now hold 156,000 square feet of office space for 670 Children's Hospital employees.
The renovation cost $38 million and 51 percent of the building is owned by Real Estate Enterprises for African American Leaders, LLC.
The hotel is modeled after the stately Hatfield House in England. It was originally built as a retreat for wealthy Cincinnatians longing to get away from the hustle and bustle of downtown. It has hosted such guests as the Beatles, Bob Dylan, Willie Nelson, the Temptations, Judy Garland and Presidents Johnson, Kennedy and Bush Sr.