UPS spokeswoman Susan Rosenberg says 433 workers will be let go from the Hebron facility on Worldwide Blvd.
Those affected include a mix of full and part time employees.
Rosenberg says one of UPS' clients decided to bring their logistics operations in house instead of outsourcing them to UPS. She said UPS is currently seeking new clients. Those left at the facility will continue to serve smaller clients.
"It's very sad whenever we hear an announcement where jobs are going to be lost especially in this economy," said Boone County Judge-Executive Gary Moore. But Moore says while the UPS loss definitely does sting, there is a broader picture of business in the county and overall it is growing.
"The reason we work economic development so hard is we know in this volatile economy there are going to be some wins and losses and we have several projects that will together will probably add jobs. I think they'll more than make up for this announcement."
According to notice filed with Kentucky on Jan. 18, the reductions will be between March 19 and April 1, 2012.