New report shows benefits of clinical trials in Cincinnati - Cincinnati News, FOX19-WXIX TV

New report shows benefits of clinical trials in Cincinnati

CINCINNATI, OH (FOX19) -

Working in collaboration with Ohio's university medical schools and science centers, hospitals and clinical research organizations, the nation's biopharmaceutical research companies have conducted nearly 5,000 clinical trials of new medicines in the state since 1999, a new study shows. 

And of the statewide total, 2,053 clinical trials have been conducted or are still underway at research institutions in Greater Cincinnati, the study shows.

"Research in Your Backyard:  Pharmaceutical Clinical Trials in Ohio" – compiled by   Pharmaceutical Research and Manufacturers of America (PhRMA) – shows that 917 of the trials conducted in the Cincinnati area over the last 13 years have targeted the nation's and Ohio's most debilitating chronic diseases – asthma, cancer, heart disease, stroke, diabetes and mental illnesses.

Of those, 191 are still active and recruiting patients, giving some disease sufferers still looking for treatments that are best for them, a viable alternative therapeutic option to consider and discuss with their physicians.

The new PhRMA clinical trials report was discussed Friday at a news conference at Cincinnati City Hall.  PhRMA spokeswoman Kaelan Hollon, who summarized the findings of the report, stressed that clinical trials have been important to the region and the state's patients, economy and the advancement of science.  From the standpoint of patients, Hollon said many of the area's trials are still recruiting participants "and that's important because for some disease sufferers, clinical tests of new drugs could provide viable therapeutic options to discuss with their doctors.  The report's appendix helps people learn more about each trial."

Hollon also said Ohio's new medicine trials have been important for patients because biopharmaceutical companies and their local research collaborators have targeted disease wisely by concentrating on the most debilitating and widespread chronic conditions, such as cancer, diabetes and heart disease.

Clinical trials are important to the economy of the region and the state because companies hire local research institutions to conduct the tests.  And it's been estimated trials account for 45 to 75 percent of the average $1.2 billion cost of developing one new biotechnology drug.

"These trials of new medicines are a good steady source of revenue for clinical research centers," said Hollon.

The tests help to advance science and, ultimately, patient health care, she added, since many of the medications that have been clinically researched in the Buckeye State are cutting-edge biotechnology treatments, including monoclonal antibody therapies for cancer and the autoimmune disease lupus.  Monoclonal antibodies are laboratory-made versions of a naturally-occurring immune system protein that binds to and neutralizes foreign toxic substances. 

Biotechnology drugs are the result of novel biological processes that give biopharmaceutical companies the strong potential to develop safer and more effective treatments. 

"Through biotechnology, we are improving our ability to predict, preempt and even prevent disease," said Hollon. 

New drug trials that have been conducted in Greater Cincinnati since 1999 are critical to the development of medicines, accounting for up to seven of the 10 to 15 years required to develop a therapy.  Large volumes of technical and scientific data – sometimes tens of thousands of pages – are generated and the tests involve participation by thousands of patients.

"This testing is so extensive because clinical trials help to establish product safety and effectiveness and allow the Food and Drug Administration to approve new medications," said Dr. Salvatore Alesci, PhRMA's vice president of scientific affairs.

Research institutions in Greater Cincinnati that have conducted or are conducting trials include:

ASTHMA

  • Cincinnati Children's Hospital Medical Center
  • Bernstein Clinical Research Center
  • New Horizons Clinical Research

CANCER

  • The Christ Hospital
  • Cincinnati Children's Hospital Medical Center
  • Greater Cincinnati OB/GYN
  • Oncology Hematology Care
  • TriState Urologic Services
  • University of Cincinnati Cancer Institute
  • University of Cincinnati Physicians

DIABETES

  • Community Research
  • MedPace Clinical Pharmacology
  • Sterling Research Group
  • The Lindner Research Center at Christ Hospital
  • University of Cincinnati

HEART DISEASE

  • Carl and Edyth Lindner Center for Research and Education at The Christ Hospital
  • Cincinnati Children's Hospital Medical Center
  • University of Cincinnati Medical Center

MENTAL ILLNESS

  • The Christ Hospital
  • Cincinnati Addiction Research Center
  • Cincinnati Children's Hospital Medical Center
  • Cincinnati VA Medical Center
  • Community Research
  • University of Cincinnati Department of Psychiatry and Behavioral Neuroscience
  • Lindner Center of HOPE at the University of Cincinnati
  • Patient Priority Clinical Sites
  • University of Cincinnati

STROKE

  • Lindner Clinic Trial Center
  • University of Cincinnati
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