Benjamin Mizukawa, M.D., received a $330,000 St. Baldrick's Scholar award,
for a period of three years, to support his work focused on acute myeloid
leukemia (AML). Although most leukemia cells are readily killed by
chemotherapy, if the leukemia stem cell escapes therapy, the child will
eventually succumb to the disease.
"We are studying how leukemia stem cells maintain
self-renewal, or the ability to give rise to new leukemia cells," explains Dr.
Mizukawa. "By understanding the signals needed for self-renewal, we hope to
identify new drugs to eliminate the leukemia stem cell and prevent relapsed
Pleuropulmonary blastoma (PPB) is a rare lung cancer of
young children. Inherited genetic mutations have been recently identified in a
gene known as DICER1 that predisposes children to developing PPB as well as
other childhood tumors arising in the muscle, brain, ovary and kidneys.
laboratory research is complimented by the first-ever prospective clinical
study of PPB therapy.
The goal of these collaborative studies is to identify
key signals responsible for PPB tumor development and growth, and also define
optimal treatment for children with all stages of PPB.
"We aim to understand why and how some kids develop tumors
and others do not. We also are focused on determining why kids with the
same tumor respond differently to treatment," said Kathryn Wikenheiser-Brokamp,
M.D., Ph.D., lead physician-scientist at Cincinnati Children's. "Our goal is to
then use what we learn to improve the lives of each child with cancer by giving
them the best treatment possible."
Through the vigorous efforts of
volunteers and supporters in the U.S. and around the world, the Foundation is
not only honored to award this local grant, but will fund a total of more than $22 million in its
2013 summer grant cycle.
Saturday, May 26 2018 11:23 PM EDT2018-05-27 03:23:47 GMT
Sunday, May 27 2018 5:28 AM EDT2018-05-27 09:28:05 GMT
(AP Photo/Rogelio V. Solis). Tommy Whitlock, left, places a filled sand bag onto his trailer at a Harrison County Road Department sand bag location, as his friend Joseph Buckner adjusts the load while preparing for Subtropical Storm Alberto to make its...
The governors of Florida, Alabama and Mississippi all declared states of emergency ahead of the storm.