Eastbound Interstate 74 remains shut down near the Colerain Avenue/Beekman Street exit due to a fatal , wrong-way crash overnight, Cincinnati police said.
The ramp from Montana Avenue onto I-74 also is closed.
It's not clear when the highway and ramp will reopen.
A female driver was pronounced dead at the scene about 2:30 a.m., said Sgt. Dean Chapman.
She went the wrong way in the westbound lanes and crossed over into eastbound traffic, slamming head-on into a semi tractor trailer, he said.
The semi driver was not hurt.
Their names were not released.
Cincinnati’s traffic unit is investigating the cause of the crash. It was not immediate clear if alcohol and/or drugs or speed are factors.