Speed and impairment appear to be factors in a crash involving a camping trailer and truck on Interstate 75 that AirCare responded to Wednesday, Cincinnati police said.
Crews responded to the southbound lanes of the highway just after Harrison Avenue about 4:47 p.m.
Charles Sell, 63, the driver of a 2006 Ford F-250 towing a 2009 Sierra camper, slowed in in traffic and was struck by a 204 Ford F-150, traffic police said in a prepared statement.
Sell and his passenger were not hurt, but the driver of the F-150 that struck Sell's vehicle had to be extricated from his truck by fire crews.
The driver was flown to University of Cincinnati Medical Center with serious injuries.
A passenger in the F-150 was taken to the hospital by ambulance with serious injuries.
The names of the driver and passenger in the F-150 will be released once their next of kin is notified, police said.
The crash remains under investigation.
Witnesses are asked to call Cincinnati Police Traffic Unit: 513-352-2514.
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