The state had executed a man who said a brain abnormality may have affected his behavior when he raped and killed a Cincinnati woman in 1987.
47 year old William H. Smith's execution went forward after courts ruled that medical tests did not prove he had brain damage.
Attorney General's spokesperson Kim Norris says Smith was pronounced dead at 10:19 am at the Southern Ohio Correctional Facility in Lucasville.
Smith was convicted of stabbing, then raping Mary Bradford of Cincinnati. His lawyers didn't challenge his conviction by say a brain lesion detected after he fainted in prison could have spared him from the death sentence at his 1988 trial.