HEBRON, KY (FOX19) - AirCare responded to a serious crash with four people hurt early Wednesday, according to the Boone County Sheriff's Office.
Four vehicles collided on Kentucky 237 at Wright Boulevard about 5:20 a.m., said sheriff's spokesman Tom Scheben.
The impact ripped the roof off one of the vehicles, a Honda Accord.
Scheben said the Accord's female driver was traveling the wrong way - southbound in the northbound lanes - on Kentucky 237 when she struck two vehicles.
Her vehicle proceeded on the wrong way and struck an oncoming pickup truck, he said.
The male driver of the pickup truck was trapped inside his vehicle, which caught fire. He was rescued by first responders who pulled him from the truck, according to Scheben.
The man suffered severe leg injuries and was driven by ambulance to University of Cincinnati Medical Center, according to the sheriff's office.
The driver of the Accord was trapped inside and had to be extricated by fire crews. She was flown to UCMC.
Two other people who were hurt were taken to St. Elizabeth Hospital.
The names and conditions of all the injured were not released.
Kentucky 237 was shut down for about four hours while the sheriff's office investigated. It reopened just after 9:30 a.m.